Biodesy has developed a novel optical platform to rapidly measure structural changes of biological molecules in real time, based on a phenomenon called second-harmonic generation (SHG). By changing conformation, proteins and other biological molecules modulate function, interact with different molecules, and participate in multiple molecular pathways. Therefore, characterizing these changes provides significant insights into how different biomolecules function and respond to different protein partners, native ligands, drug candidates, etc. Biodesy’s mass-independent, SHG-based detection of structural changes enables high-throughput, robust assays to directly monitor binding-induced structural changes in a wide array of biomolecular drug targets, from RNA to large protein complexes.
