INTRODUCTION TO SHG

COMPETITIVE ADVANTAGE

Biodesy’s second-harmonic generation (SHG) technology’s unique attributes:

  • Ligand-induced protein structural changes measured in real time
  • Sensitivity to angular changes of < 1 degree
  • Conformation-specific response to ligand stimulation
  • Live, functional protein, not crystal
  • Read time of seconds
  • Compatible with targets of any size
  • Minimal protein consumption (<100 ng/well)
  • Compatible with fragment screening
  • Labeling need not be site-specific

APPLICATIONS

Biodesy’s breakthrough platform enables new drug discovery paradigms,
and has been used for a broad spectrum of target classes.
Examples include:

  • Protein kinases
  • Adenylate kinase
  • Integrins
  • DHFR
  • Alpha-synuclein
  • Beta amyloid
  • Calmodulin

PUBLICATIONS