Representative Data
Target =Integrin αvβ3
Surface = Streptavidin or PEG
SHG Label = PyMPO
Active Ligand = 200µM GRGDSP
Inactive Ligand = 200µM GRGESP
>45° rotation
Movie of cRGD-induced onformational change of integrin protein
Movie courtesy of Tim Springer's lab at Harvard. Movies are extrapolations between EM and crystal structures described in Xiao, T., et al. (2004). Structural basis for allostery in integrins and binding of fibrinogen-mimetic therapeutics. Nature 432, 59-67. #16500 |
