Discovery of Selective RNA-Binding Small Molecules by Affinity-Selection Mass Spectrometry

Rizvi NF, Howe JA, Nahvi A, Klein DJ, Fischmann TO, Kim HY, McCoy MA, Walker SS, Hruza A, Richards MP, Chamberlin C, Saradjian P, Butko MT, Mercado G, Burchard J, Strickland C, Dandliker PJ, Smith GF, Nickbarg EB. ACS Chem Biol. (2018).

Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation

Wong, J.J.W.; Young, T.A.; Zhang, J.; Liu, S.; Leser, G.P.; Kornives, E.A; Lamb, R.A; Hong Zhou, Z.; Salafsky, J.; Jardetzky, T.S.; Nature Communications. (2017).

Evaluating the contribution of transition state destabilization to changes in the residence time of triazole-based InhA inhibitors

Spagnuolo, L.A.; Eltschkner, S.; Yu, W.; Daryaee, F.; Davoodi, S.; Knudson, S.E.; Allen, E.K.H.; Merino, J.; Pschibul, A.; Moree, B.; Thivalapill, N.; Truglio, J.J.; Salafsky, J.; Slayden, R.A.; Kisker, C. and Tonge, P.J.; Journal of the American Chemical Society. (2017).

Second-harmonic phase determination by real-time in situ interferometry

Clancy, B. and Salafsky, J. Physical Chemistry Chemical Physics. 19, 3722-3728 (2017).

ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis

Ma, B.; Marcotte, D.; Paramasivam, M.; Michelsen, K.; Wang, T.; Bertolotti-Ciarlet, A.; Jones, J.H.; Moree, B.; Butko, M.; Salafsky, J.; Sun, X.; McKee, T. and Silvian, L.F. PLoS ONE 11 e0165983 (2016).

Detection of ligand-induced conformational changes in oligonucleotides by second-harmonic generation at a supported lipid bilayer interface

Butko, M.T; Moree, B.; Mortensen, R.B. and Salafsky, J. Analytical Chemistry. 88 (21), pp 10482–10489 (2016).

Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric Alpha-Synuclein and Reduce its Aggregation in Cells

Moree, B.; Yin G.; Lázaro, D.F.; Munari, F.; Strohäker, T.; Giller, K.; Becker, S.; Outeiro, T.F.; Zweckstetter, M. and Salafsky, J. The Journal of Biological Chemistry. 290, 27582 – 27593 (2015).

Protein Conformational Changes Are Detected and Resolved Site Specifically by Second-Harmonic Generation

Moree, B.; Connell, K.; Mortensen, R.B.; Liu, C.T.; Benkovic, S.J. and Salafsky, J. Biophysical Journal. 109, 806 – 815 (2015)

A second-harmonic-active unnatural amino acid as a structural probe of biomolecules on surfaces

Salafsky, J.S and Cohen, B. A. The Journal of Physical Chemistry B. 112, 15103 – 15107 (2008).

Second-harmonic generation for studying structural motion of biological molecules in real time and space

Salafsky, J.S. Physical Chemistry Chemical Physics. 9, 5704 – 5711 (2007).

Detection of protein conformational change by optical second-harmonic generation

Salafsky, J.S. The Journal of Chemical Physics. 125, 074701 (2006).

Second-harmonic generation as a probe of conformational change in molecules

Salafsky, J.S. Chemical Physics Letters. 381, 705 – 709 (2003).