Scientist/Sr Scientist – Biochemistry


We are seeking a talented and highly-motivated Scientist/Sr. Scientist to join our collaborative discovery team to support small-molecule hit discovery using Biodesy’s proprietary technology for measuring protein structural changes. As a part of the team, they will play a central role in defining and executing on strategies to design small-molecule screening assays to drug novel therapeutic targets. To join the dynamic, fast-paced, and venture-funded biotech team, the successful candidate will have a strong background in development, optimization and execution of biochemical or biophysical assays to probe protein structure and/or function. The ideal candidate will be self-driven, resourceful, organized, and enjoy working in a dynamic team environment.


  • In collaboration with the team, the Scientist/Sr. Scientist will develop strategies to monitor functionally relevant structural changes in protein conformations
  • Will design, develop and optimize biochemical and biophysical assays for relevant targets
  • Establish high-throughput screening (HTS) assays and demonstrate feasibility
  • Lead HTS campaigns including execution, data analysis and subsequent hit triaging and follow-up
  • Oversee protein design, engineering, expression and purification to support hit discovery efforts
  • Work closely with other team members with the expectation to mentor junior associates
  • Communicate findings to the team including scientific presentations to the whole company


  • Ph.D. in Biochemistry, Biophysics, Structural Biology or a related discipline is required. Prior industry experience and/or post-doctoral experience is a plus. Minimum 3 years of prior drug discovery experience in industry setting required for Senior Scientist role (level and compensation commensurate with experience)
  • Deep knowledge with hands on experience in conceptualizing and developing biochemical and/or biophysical assays using structural and mechanistic insights
  • Expertise in protein biochemistry including protein engineering, expression and purification
  • Prior experience with small molecule discovery including HTS is preferred
  • Excellent communication skills and ability to present rationale, key data, issues and progress to other team members including management team
  • Good fit with Biodesy culture and values of highly collaborative, team-oriented work


  • Full time employee at Biodesy, Inc.
  • Located in South SF
  • Please submit resume or CVs to