How to Access Our Technology

The Biodesy Delta™ measures compound-induced structural and conformational changes of biological molecules with high throughput (384- or 1536-well) and low target biomolecule consumption, compared to other structural techniques. Utilizing orientation-sensitive second-harmonic generation (SHG) technology, the Delta detects very subtle (sub-Å) changes in a target biomolecule’s structure to help you gain structural insights earlier in the drug discovery pipeline.

Opportunities to Engage

Services that Harness Structural Changes to Meet Your Drug Discovery Needs


  • Identify new chemical matter that binds to a target of interest, including difficult-to-drug targets
  • Differentiate compounds by induced structural changes: binding mode
  • Evaluate dual effect of two compounds against a target of interest: order of addition
  • Measure protein-protein interactions
  • Drug protein complexes

Customized Services

  • Assay development for a variety of targets, including challenging target classes
  • High-throughput screening (>100,000 drug candidates/week) to detect on-target interactions
  • Evaluate mechanism of action: antagonists vs. agonists; allosteric vs. orthosteric
  • Characterize differences in binding-induced structural changes among a series of molecules
  • Protein design for enhanced assay development


Learn More About Opportunities to Engage with Biodesy

We are interested in learning more about how we can enable your drug discovery efforts through measurement of structural and conformational changes, and we look forward to hearing from you.

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